17 May 2023

 


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25 April 2023

Cheating leads to the evolution of multipartite viruses. This paper proposing an explanation to how some viruses end up splitting their genomes into separate pieces packaged separately. Previous explanations of why this could be advantageous seemed forced to me, so the idea that this is the consequence of extreme “cheating” by viral free riders is pretty intriguing. A cool story of ecological dynamics, game theory concepts, evolution, viruses, and math! https://doi.org/10.1371/journal.pbio.3002092
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28 Sep 2023

Hello interwebz!   Back for #Evoluncheons after a week of travel and drowning in a sea of papers. This took all day again -_-    Actually organizing by #evolution themes from now on, hopefully easier to digest: Fundamentals: Strong environmental memory revealed by experimental evolution in static and fluctuating environments . Switching barcoded yeast mutants between carbon sources leads to results that are different from what we would expect based on their fitness in each carbon source without switching. Mutants with greater differences in fitness between static environments show the greatest deviations from expectation. https://doi.org/10.1101/2023.09.14.557739 https://twitter.com/clabreu/status/1706324819631862158   A direct experimental test of Ohno's hypothesis . Susumu Ohno proposed gene duplications should facilitate evolution of proteins with novel functions. FACS-powered experimental evolution of fluorescent protein libraries confirms duplications incr...
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13 Aug 2023

There are lots of papers this week, buckle up Predicting evolutionary outcomes through the probability of accessing sequence variants . Thanks Sarah for sharing this one! This is such a simple but important idea. Essentially, evolution follows not only the contours of the fitness landscape but also the “genotype-accessibility landscape”, which is shaped by stuff like codon bias and biochemical mechanisms of mutation changing the likelihoods of some mutations. They look at some examples of this in fu. https://www.science.org/doi/full/10.1126/sciadv.ade2903   Purifying selection and adaptive evolution proximate to the zoonosis of SARS-CoV-1 and SARS-CoV-2 . These folks do some population genetics archaeology to try to put together what was happening with the genomes of SARS-CoV-1 and SARS-CoV-2 around the time they jumped into humans. They find most things are under purifying selection (which is generally the case with viruses as they “live on the (evolut...
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